Hifumi's Study Notes

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DNA Replication ​

Tags
Cegep1
Biology
Word count
169 words
Reading time
2 minutes

Process during S phase in which DNA makes a copy of itself
Semiconservative (one original strand is preserved in each copy)

Enzymes ​

Steps ​

Initiation ​

  1. Helicases bind to origins of replication and begin unwinding DNA to form a replication bubble with two replication forks, each fork with two strands.
  2. Single-stranded binding proteins bind to the template DNA to keep them separated.

Elongation ​

Synthesis of the complementary strands

Different for the two strands

Leading strand ​

5' to 3' continuous DNA synthesis in the same direction of DNA unwinding
One RNA primer

  1. Primase makes a complementary RNA primer
  2. DNA polymerase adds

Lagging strand ​

3' to 5' discontinuous DNA synthesis in the opposite direction of DNA unwinding
Many RNA primers

  1. Primase makes a complementary RNA primer
  2. DNA polymerase adds

Termination ​

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